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Alkaline Peptides
MOTS-C
MOTS-C
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A mitochondrial-derived peptide at the center of modern metabolism and exercise research.
MOTS-C is a 16-amino-acid peptide encoded within mitochondrial DNA — one of very few peptides made by the mitochondria themselves. It has become a major focus of research into cellular energy, metabolism and exercise physiology.
What MOTS-C is
- A mitochondrial-derived peptide (MDP) — encoded in the 12S rRNA region of mitochondrial DNA
- Discovered in 2015, making it one of the newer peptides in metabolic research
- Sometimes called an "exercise-mimetic" in the literature because of how it is studied
Research suggests MOTS-C may help with
- Metabolic regulation — glucose uptake and insulin-sensitivity models
- Cellular energy — AMPK pathway activation studies
- Exercise capacity — endurance and performance in animal models
- Fat metabolism — fatty-acid oxidation research
- Healthy aging — mitochondrial function across lifespan studies
Research areas at a glance
| Research area | What studies explore |
|---|---|
| Metabolism | Glucose handling and insulin signaling in preclinical models |
| AMPK pathway | Activation of the cell's master energy sensor |
| Exercise physiology | Endurance and muscle energetics in rodent studies |
| Aging biology | Mitochondrial communication with the nucleus over time |
How MOTS-C is studied to work
1. AMPK activation
- Studied for switching on AMPK, the cell's energy-status sensor
- AMPK activation is associated in research with increased glucose uptake and fat oxidation
2. Mitochondria-to-nucleus signaling
- Researched as a retrograde signal — mitochondria telling the nucleus what genes to express
- Studied for translocating to the nucleus under metabolic stress
3. Muscle energetics
- Explored in exercise models for endurance-related outcomes
- Studied for skeletal-muscle glucose utilisation
👉 Think: a metabolic messenger, not a stimulant

Product specifications
| Specification | Detail |
|---|---|
| Vial size | 10mg MOTS-C |
| Form | Lyophilized (freeze-dried) powder |
| Storage | Cool, dry place away from light; refrigerate after reconstitution |
| Intended use | Laboratory research only — not for human consumption |
Summary
In research settings, MOTS-C is studied for:
- Mitochondrial-derived signaling peptide
- AMPK and glucose-metabolism research
- Exercise-physiology and aging studies
MOTS-C is NOT a fat-loss drug — it is studied as a cellular-energy optimizer.
Metabolism research moves fast — MOTS-C is one of the few tools that lets you probe the mitochondrial side of the equation directly.
Secure MOTS-C 10mg for your research program today.
For laboratory research only. This product is not approved for human consumption, therapeutic use, or diagnostic applications. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. Nothing on this page is medical advice.
Product Details
Product Details
A mitochondrial-derived peptide at the center of modern metabolism and exercise research.
MOTS-C is a 16-amino-acid peptide encoded within mitochondrial DNA — one of very few peptides made by the mitochondria themselves. It has become a major focus of research into cellular energy, metabolism and exercise physiology.
What MOTS-C is
- A mitochondrial-derived peptide (MDP) — encoded in the 12S rRNA region of mitochondrial DNA
- Discovered in 2015, making it one of the newer peptides in metabolic research
- Sometimes called an "exercise-mimetic" in the literature because of how it is studied
Research suggests MOTS-C may help with
- Metabolic regulation — glucose uptake and insulin-sensitivity models
- Cellular energy — AMPK pathway activation studies
- Exercise capacity — endurance and performance in animal models
- Fat metabolism — fatty-acid oxidation research
- Healthy aging — mitochondrial function across lifespan studies
Research areas at a glance
| Research area | What studies explore |
|---|---|
| Metabolism | Glucose handling and insulin signaling in preclinical models |
| AMPK pathway | Activation of the cell's master energy sensor |
| Exercise physiology | Endurance and muscle energetics in rodent studies |
| Aging biology | Mitochondrial communication with the nucleus over time |
How MOTS-C is studied to work
1. AMPK activation
- Studied for switching on AMPK, the cell's energy-status sensor
- AMPK activation is associated in research with increased glucose uptake and fat oxidation
2. Mitochondria-to-nucleus signaling
- Researched as a retrograde signal — mitochondria telling the nucleus what genes to express
- Studied for translocating to the nucleus under metabolic stress
3. Muscle energetics
- Explored in exercise models for endurance-related outcomes
- Studied for skeletal-muscle glucose utilisation
👉 Think: a metabolic messenger, not a stimulant

Product specifications
| Specification | Detail |
|---|---|
| Vial size | 10mg MOTS-C |
| Form | Lyophilized (freeze-dried) powder |
| Storage | Cool, dry place away from light; refrigerate after reconstitution |
| Intended use | Laboratory research only — not for human consumption |
Summary
In research settings, MOTS-C is studied for:
- Mitochondrial-derived signaling peptide
- AMPK and glucose-metabolism research
- Exercise-physiology and aging studies
MOTS-C is NOT a fat-loss drug — it is studied as a cellular-energy optimizer.
Metabolism research moves fast — MOTS-C is one of the few tools that lets you probe the mitochondrial side of the equation directly.
Secure MOTS-C 10mg for your research program today.
For laboratory research only. This product is not approved for human consumption, therapeutic use, or diagnostic applications. It has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. Nothing on this page is medical advice.
Reconstitution / BAC Water
Reconstitution / BAC Water
All vial peptides are supplied in lyophilized powder form for research purposes. Reconstitution / BAC Water requires bacteriostatic (BAC) water, and the amount used depends on the concentration required for your research protocol.
Storage & Handling
Storage & Handling
Before reconstitution, keep sealed vials cool, dry, and away from direct light. For longer-term storage, freezing is recommended to preserve stability.
After reconstitution, store refrigerated and use within 30 days for best stability.
Who Is It For?
Who Is It For?
This page is intended for buyers already familiar with peptide research products who want a fast, simple way to choose in-stock items and complete checkout quickly.

MOTS-C
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